
Professor, Pediatrics
M_PEDS-NEONATOLOGY
+1 415 476-9313
Publications
Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation.
Scientific reports
Restoration of pp60Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells.
International Journal of Molecular Sciences
Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.
Stroke
Pre-eclampsia and barker's hypothesis: are we beginning to see the trees within the forest?
Pediatric research
OMX: A Novel Oxygen Delivery Biotherapeutic Improves Outcomes in an Ovine Model of Controlled Hemorrhagic Shock.
Shock (Augusta, Ga.)
The effect of fertility treatment and socioeconomic status on neonatal and post-neonatal mortality in the United States.
Journal of perinatology : official journal of the California Perinatal Association
3 Development, Function, and Pathology of the Placenta.
Avery's Diseases of the Newborn
Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy.
Children (Basel, Switzerland)
Fertility treatment increases the risk of preterm birth independent of multiple gestations.
F&S Reports
Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetrical disease.
American journal of obstetrics and gynecology
Defining longer term outcomes in an ovine model of moderate perinatal hypoxia-ischemia.
Developmental neuroscience
Autophagy plays a key role in hyper-proliferative phenotype in pulmonary vascular diseases.
Free Radical Biology and Medicine
Outcomes of Very Preterm Infants Conceived with Assisted Reproductive Technologies.
The Journal of pediatrics
Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant.
Nature biotechnology
HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow.
Scientific reports
Sex-specific epigenetic profile of inner cell mass of mice conceived in vivo or by IVF.
Molecular human reproduction
Defining the ATPome reveals cross-optimization of metabolic pathways.
Nature communications
Human placental trophoblast progenitor cells (hTPCs) promote angiogenesis and neurogenesis after focal cerebral ischemia in rats.
The International journal of neuroscience
Complex interplay between autophagy and oxidative stress in the development of pulmonary disease.
Redox biology
Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease.
Pulmonary circulation
Mechanical Forces Alter Endothelin-1 Signaling: Comparative Ovine Models of Congenital Heart Disease.
Biophysical Journal
Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age.
Pediatric pulmonology
Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling.
American journal of respiratory cell and molecular biology
Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury.
Frontiers in physiology
The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification.
PloS one
Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease.
Antioxidants & redox signaling
Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.
PLoS biology
KLF2-mediated disruption of PPAR-γ signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.
American journal of physiology. Heart and circulatory physiology
Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury.
Cerebellum (London, England)
Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Common and specific transcriptional signatures in mouse embryos and adult tissues induced by in vitro procedures.
Reproduction (Cambridge, England)
Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation.
American journal of physiology. Heart and circulatory physiology
Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.
American journal of physiology. Heart and circulatory physiology
Adult male mice conceived by in vitro fertilization exhibit increased glucocorticoid receptor expression in fat tissue.
Journal of developmental origins of health and disease
Placenta: the forgotten organ.
Annual review of cell and developmental biology
Abstract 640: PASMC Hyperproliferation and Metabolic Shift in a Model of Pulmonary Overcirculation.
Arteriosclerosis Thrombosis and Vascular Biology
HIGD1A-mediated dormancy and tumor survival.
Molecular & cellular oncology
Spare hypoxia, spoil the child?
The Journal of clinical investigation
LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.
The American journal of pathology
Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes.
Endocrinology
Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis.
Cell
Therapeutic delivery of placental stem cells to modulate vasculature and promote fracture repair (342.6).
The FASEB Journal
Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis.
Endocrinology
Hypoxia and trophoblast differentiation: a key role for PPARγ.
Stem cells and development
The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos.
Disease models & mechanisms
Effect of ICSI on gene expression and development of mouse preimplantation embryos.
Human Reproduction
In vitro culture of mouse embryos reduces differential gene expression between inner cell mass and trophectoderm.
Reproductive sciences (Thousand Oaks, Calif.)
A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.
Development (Cambridge, England)
Effect of ICSI on gene expression and development of mouse preimplantation embryos.
Human reproduction (Oxford, England)
Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care.
Seminars in fetal & neonatal medicine
Effect of the method of conception and embryo transfer procedure on mid-gestation placenta and fetal development in an IVF mouse model.
Human reproduction (Oxford, England)
The placenta: transcriptional, epigenetic, and physiological integration during development.
The Journal of clinical investigation
Oxygen in health and disease: regulation of oxygen homeostasis--clinical implications.
Pediatric research
Role of oxygen in early development and embryonic stem cell derivation.
Stem Cells in Human Reproduction
Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
Journal of Clinical Investigation
Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
The Journal of clinical investigation
Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
Lymphatic research and biology
Oxygen, epigenetics and stem cell fate.
Regenerative medicine
Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation.
Molecular and cellular biology
Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta.
Development (Cambridge, England)
Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses.
Genes & development
Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses.
Genes & development
TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs.
The American journal of pathology
The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia.
Biochemical and biophysical research communications
HIF-1 is essential for multilineage hematopoiesis in the embryo.
Advances in experimental medicine and biology
Multilineage embryonic hematopoiesis requires hypoxic ARNT activity.
Genes & development
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.
Proceedings of the National Academy of Sciences of the United States of America
Oxygen, genes, and development: an analysis of the role of hypoxic gene regulation during murine vascular development.
Journal of molecular medicine (Berlin, Germany)
Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.
Mechanisms of Development
The use of methylthioadenosine phosphorylase activity to select for human chromosome 9 in interspecies and intraspecies hybrid cells.
Somatic cell and molecular genetics